ASSESSMENT OF ANTI-PSORIATIC EFFICACY OF MANGIFERA INDICA FLOWER EXTRACTS OBTAINED USING DIFFERENT SOLVENTS

Abstract

Psoriasis is a chronic inflammatory skin disorder that necessitates the development of safe and effective therapeutic alternatives derived from natural sources. This study examines the impact of different extraction solvents on the anti-psoriatic potential of Mangifera indica flower extracts. The flowers were extracted using solvents of varying polarity—aqueous, methanolic, ethanolic, and non-polar—to obtain diverse phytochemical fractions.

The resulting extracts were analyzed for their phytochemical profiles and evaluated for anti-psoriatic activity through relevant in vitro assays related to inflammation and keratinocyte proliferation. The findings revealed that solvent polarity markedly influenced extraction yield, phytochemical composition, and biological activity. Extracts obtained with polar solvents contained higher concentrations of phenolic and flavonoid compounds and demonstrated greater anti-inflammatory and anti-proliferative effects than non-polar fractions.

Overall, the results indicate that optimizing solvent selection significantly enhances the therapeutic potential of Mangifera indica flowers, supporting their promise as a natural source for developing anti-psoriatic formulations. This study underscores the critical role of extraction strategies in maximizing the pharmacological efficacy of plant-derived bioactive compounds.